SYDNEY， Feb. 23 (Xinhua) -- Australian scientists have discovered a potent molecule responsible for inflammatory diseases.
In a study published on Thursday， researchers form Melbourne's Walter and Eliza Hall Institute (WEHI) found that an inflammatory molecule released by dying cells triggers inflammation during necroptosis， a form of cell death linked to inflammatory disease.
Necroptosis is a process for protecting humans from infections by sacrificing infected or diseased cells "for the greater good."
However， if necroptosis becomes excessively activated it can trigger damaging inflammation that leads to inflammatory disease.
Lisa Lindqvist， the lead researcher， said that interleukin-1 beta (IL-1b) triggered inflammation during the cell death.
She said the discovery challenged a long-standing dogma that inflammation triggered by necroptosis was a by-product of dead cell debris.
"Our research has pinpointed that， during necroptosis， dying cells release IL-1b， a potent inflammatory signal，" Lindqvist said in a media release on Thursday.
"Now that we have discovered IL-1b is the 'root' of the inflammation associated with necroptosis， we speculate that targeting this molecule could be an effective way of treating inflammatory diseases."
Researchers are optimistic that the findings suggest suppressing IL-1b would reduce inflammation associated with inflammatory diseases such as multiple sclerosis (MS)， liver disease and pancreatitis.
"Our research suggests that existing drugs that block IL-1b might be useful in treating these diseases，" Lindqvist said.
"We are also exploring how IL-1b is signalled to be secreted during necroptosis， so that we can create new drugs to stop its release and reduce inflammation to treat inflammatory diseases."
In February 2009 Hakan Calhanoglu Jersey , the American Recovery & Reinvestment Act of 2009 (ARRA) provided a comprehensive plan to stimulate the economy, which included over $20 billion in grants, loans and incentives for the development of a strong IT infrastructure in America’s heath care system. To receive these incentives Gustavo Gomez Jersey , hospitals and clinics must demonstrate “meaningful use,” which ARRA has defined through three stages that clinicians must achieve when implementing Electronic Health Records (EHR).
It is definitely a challenge to achieve ARRA-defined meaningful use, but the benefits are immeasurable for patients Gianluigi Donnarumma Jersey , hospitals and clinicians. Using ARRA’s three stages as a guideline, your planning team can effectively develop a strategy and timeline for successfully achieving meaningful use.
Developing a Meaningful Use Strategy
The most important step in strategically planning for meaningful use is to assess your EHR system and ensure that it is ARRA-certified. Whether upgrading your current system or integrating a new one, a certified EHR system plays a pivotal role in laying a foundation for meeting each criteria in the three stages of meaningful use. It is crucial to get both clinical and technical staff involved as soon as possible Giacomo Bonaventura Jersey , since the changes ahead will directly affect their workflow in both the short- and long-term.
This can be accomplished in phases, which will help you understand what needs to happen first. Stages Two and Three build incrementally on the work you do in Stage One, so the better prepared you are Gabriel Paletta Jersey , the smoother the next stage will be.
Concurrent with determining an EHR solution, devise a strategy for training, implementation and assessment. Explain the three stages Gabriel Jersey , the goals of each, and the benefits to all involved. Then work with your team to develop and maintain a firm timeline for meeting each of the criteria.
Creating a Meaningful Use Timeline
Hospitals and health care professionals who are unable to demonstrate meaningful use by October 2014 (fiscal year 2015 for hospitals) or January 2015 (calendar year 2015 for eligible professionals) will not only forego the meaningful use incentive payments but will also receive a reduced annual payment rate from Medicare and Medicare Advantage for every year they have not achieved meaningful use.
Because of these deadlines, it is vital to establish a firm timeline that details a specific date by which each team member must accomplish set goals. Establishing deadlines will ensure that you are efficiently meeting the requirements of each phase. Throughout the process Franck Kessie Jersey , it is important to help team members recognize the long-term, significant impact of their efforts.
Implementing Meaningful Use
If you need more information about the implementation of meaningful use and how it improves efficiency for medical professionals, contact e-MDs Fabio Borini Jersey , a leader in electronic medical record software provision. e-MDs will help you understand how to use your new EHR system or assess and upgrade your current system in a way that achieves ARRA-defined meaningful use.
e-MDs offers a host of affordable, certified EHR solutions for physicians and facilities looking to modernize or enhance their services with the latest electronic health records technology. e-MDs is committed to providing affordable and integrated EHR and Practice Management Software solutions, including clinical Davide Calabria Jersey , financial and document management modules designed to automate medical practice processes and chart management – delivering the clinical tools needed to succeed in today’s health care environment. You can find additional detailed information about all the different services and benefits an EHR system has to offer your practice by contacting a representative right now at 1.888.344.9836 or sales@e-mds, or visiting them online at www.e-mds.